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1

Altered profile of human gut microbiome is associated with cirrhosis and its complications

Bajaj, Jasmohan S., Heuman, Douglas M., Hylemon, Phillip B., Sanyal, Arun J., White, Melanie B., Monteith, Pamela, Noble, Nicole A., Unser, Ariel B., Daita, Kalyani, Fisher, Andmorgan R., Sikaroodi, M

Journal:

Journal of Hepatology

Year:

2014

Language:

english

File:

PDF, 1.20 MB

english, 2014

2

Regulation of bile acid synthesis

Z. Reno Vlahcevic, Douglas M. Heuman, Phillip B. Hylemon

Journal:

Year:

1991

Language:

english

File:

PDF, 1.34 MB

english, 1991

3

Sulfated oxysterol, 25HC3S, is a potent regulator of lipid metabolism in human hepatocytes

Shunlin Ren, Xiaobo Li, Daniel Rodriguez-Agudo, Gregorio Gil, Phillip Hylemon, William M. Pandak

Journal:

Biochemical and Biophysical Research Communications

Year:

2007

Language:

english

File:

PDF, 222 KB

english, 2007

4

Positive and negative regulation of JNK1 by protein kinase C and p42MAP kinase in adult rat hepatocytes

W.David Jarvis, Kelly L Auer, Mark Spector, George Kunos, Steven Grant, Philip Hylemon, Ross Mikkelsen, Paul Dent

Journal:

Year:

1997

Language:

english

File:

PDF, 799 KB

english, 1997

5

313 25-Hydroxycholesterol-3-Sulfate (25HC3S) Attenuates Hepatocyte Intracellular Lipid Levels and Inflammatory Response via LXR/Srebps and IKB/NF-kB Pathways

Xu, Leyuan, Bai, Qianming, Hylemon, Phillip, Heuman, Douglas M., Pandak, William M., Ren, Shunlin

Journal:

Gastroenterology

Year:

2010

Language:

english

File:

PDF, 91 KB

english, 2010

6

Consequences of bile salt biotransformations by intestinal bacteria

Ridlon, Jason M., Harris, Spencer C., Bhowmik, Shiva, Kang, Dae-Joong, Hylemon, Phillip B.

Journal:

Year:

2016

Language:

english

File:

PDF, 1.77 MB

english, 2016

7

Gut microbiota drive the development of neuro-inflammatory response in cirrhosis

Kang, Dae Joong, Betrapally, Naga S, Ghosh, Siddhartha A, Sartor, R Balfour, Hylemon, Phillip B, Gillevet, Patrick M, Sanyal, Arun J, Heuman, Douglas M, Carl, Daniel, Zhou, Huiping, Liu, Runping, Wang

Journal:

Year:

2016

Language:

english

File:

PDF, 3.56 MB

english, 2016

8

Metabolism of hydrogen gases and bile acids in the gut microbiome

Hylemon, Phillip B., Harris, Spencer C., Ridlon, Jason M.

Journal:

Year:

2018

Language:

english

File:

PDF, 618 KB

english, 2018

9

Endoplasmic Reticulum Stress and Atherosclerosis

Zhou, Huiping, Sun, Lixin, Xiao, Jian, Zhang, Luyong, Li, Xiaokun, Studer, Elaine, Pandak, William, Hylemon, Phillip

Journal:

Current Hypertension Reviews

Year:

2010

Language:

english

File:

PDF, 281 KB

english, 2010

10

Regulation of bile acid synthesis. I. Effects of conjugated ursodeoxycholate and cholate on bile acid synthesis in chronic bile fistula rat

Douglas M. Heuman, Carmen R. Hernandez, Philip B. Hylemon, William M. Kubaska, Constance Hartman, Z. Reno Vlahcevic

Journal:

Year:

1988

Language:

english

File:

PDF, 1007 KB

english, 1988

11

Regulation of bile acid synthesis. II. Effect of bile acid feeding on enzymes regulating hepatic cholesterol and bile acid synthesis in the rat

Douglas M. Heuman, Z. Reno Vlahcevic, Marsha L. Bailey, Phillip B. Hylemon

Journal:

Year:

1988

Language:

english

File:

PDF, 761 KB

english, 1988

12

Cholesterol and bile acid metabolism in cultures of primary rat bile ductular epithelial cells

Dr. Philip B. Hylemon, Patricia M. Bohdan, Alphonse E. Sirica, Douglas M. Heuman, Z. Reno Vlahcevic

Journal:

Year:

1990

Language:

english

File:

PDF, 827 KB

english, 1990

13

Conjugates of ursodeoxycholate protect against cytotoxicity of more hydrophobic bile salts: In vitro studies in rat hepatocytes and human erythrocytes

Dr. Douglas M. Heuman, W. Michael Pandak, Philip B. Hylemon, Z. Reno Vlahcevic

Journal:

Year:

1991

Language:

english

File:

PDF, 701 KB

english, 1991

14

Role of newly synthesized cholesterol or its metabolites on the regulation of bile acid biosynthesis after short-term biliary diversion in the rat

Z. Reno Vlahcevic, William M. Pandak, Philip B. Hylemon, Douglas M. Heuman

Journal:

Year:

1993

Language:

english

File:

PDF, 1.04 MB

english, 1993

15

Effects of different bile salts on steady-state mRNA levels and transcriptional activity of cholesterol 7α-hydroxylase

William M. Pandak, Z. Reno Vlahcevic, Douglas M. Heuman, Kaye S. Redford, John Y. L. Chiang, Philip B. Hylemon

Journal:

Year:

1994

Language:

english

File:

PDF, 822 KB

english, 1994

16

Overexpression of cholesterol transporter StAR increases In Vivo rates of bile acid synthesis in the rat and mouse

Shunlin Ren, Phillip B. Hylemon, Dalila Marques, Emily Gurley, Patricia Bodhan, Elizabeth Hall, Kaye Redford, Gregorio Gil, William M. Pandak M.D.

Journal:

Year:

2004

Language:

english

File:

PDF, 886 KB

english, 2004

17

Bile acids induce mitochondrial ROS, which promote activation of receptor tyrosine kinases and signaling pathways in rat hepatocytes

Youwen Fang, Song Iy Han, Clint Mitchell, Seema Gupta, Elaine Studer, Steven Grant, Phillip B. Hylemon, Paul Dent

Journal:

Year:

2004

Language:

english

File:

PDF, 1.32 MB

english, 2004

18

Bile acids enhance the activity of the insulin receptor and glycogen synthase in primary rodent hepatocytes

Song Iy Han, Elaine Studer, Seema Gupta, Youwen Fang, Liang Qiao, Weiqun Li, Steven Grant, Philip B. Hylemon, Paul Dent

Journal:

Year:

2004

Language:

english

File:

PDF, 356 KB

english, 2004

19

Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin–sensitive mechanism in murine and human hepatocytes

Paul Dent, Youwen Fang, Seema Gupta, Elaine Studer, Clint Mitchell, Sarah Spiegel, Philip B. Hylemon

Journal:

Year:

2005

Language:

english

File:

PDF, 468 KB

english, 2005

20

Prevention of free fatty acid–induced hepatic lipotoxicity by 18β-glycyrrhetinic acid through lysosomal and mitochondrial pathways

Xudong Wu, Luyong Zhang, Emily Gurley, Elaine Studer, Jing Shang, Tao Wang, Cuifen Wang, Ming Yan, Zhenzhou Jiang, Phillip B. Hylemon, Arun J. Sanyal, William M. Pandak Jr, Huiping Zhou

Journal:

Year:

2008

Language:

english

File:

PDF, 2.17 MB

english, 2008

21

Altered levels of phosphoinositide metabolites and activation of guanine-nucleotide dependent phospholipase C in rat hepatic tumors

Narendra D. Lalwani, Philip B. Hylemon, Stephen C. Strom

Journal:

Journal of Cellular Physiology

Year:

1991

Language:

english

File:

PDF, 1.08 MB

english, 1991

22

Simultaneous measurement of cholesterol 7α-hydroxylase activity by reverse-phase high-performance liquid chromatography using both endogenous and exogenous [4-14C]cholesterol as substrate

Phillip B. Hylemon, Elaine J. Studer, William M. Pandak, Douglas M. Heuman, Z.Reno Vlahcevic, John Y.L. Chiang

Journal:

Analytical Biochemistry

Year:

1989

Language:

english

File:

PDF, 455 KB

english, 1989

23

Synthesis and anti-inflammatory activities of mono-carbonyl analogues of curcumin

Guang Liang, Xiaokun Li, Li Chen, Shulin Yang, Xudong Wu, Elaine Studer, Emily Gurley, Phillip B. Hylemon, Faqing Ye, Yueru Li, Huiping Zhou

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 181 KB

english, 2008

24

Regulation of p21 and p27 expression by the hepatitis B virus X protein and the alternate initiation site X proteins, AUG2 and AUG3

J KEVIN LEACH, LIANG QIAO, YOUWEN FANG, SONG LY HAN, DONNA GILFOR, PAUL B FISHER, STEVEN GRANT, PHILIP B HYLEMON, DARRELL PETERSON, PAUL DENT

Journal:

Journal of Gastroenterology and Hepatology

Year:

2003

Language:

english

File:

PDF, 272 KB

english, 2003

25

Expression inEscherichia coliand characterization of a bile acid-inducible 3α-hydroxysteroid dehydrogenase fromEubacteriumsp. strain VPI 12708

Darrell H. Mallonee, Mark A. Lijewski, Phillip B. Hylemon

Journal:

Current Microbiology

Year:

1995

Language:

english

File:

PDF, 533 KB

english, 1995

26

Use of a short A/T-rich cassette for enhanced expression of cloned genes inEscherichia coli

Darrell H. Mallonee, Phillip B. Hylemon

Journal:

Molecular Biotechnology

Year:

1999

Language:

english

File:

PDF, 1.87 MB

english, 1999

27

Over-expression of hepatic neutral cytosolic cholesteryl ester hydrolase in mice increases free cholesterol and reduces expression of HMG-CoAR, CYP27, and CYP7A1

Timothy B. Langston, Phillip B. Hylemon, W. M. Grogan

Journal:

Year:

2005

Language:

english

File:

PDF, 570 KB

english, 2005

28

Mitochondrial cholesterol transport: A possible target in the management of hyperlipidemia

E. A. Hall, S. Ren, P. B. Hylemon, K. Redford, A. del Castillo, G. Gil, W. M. Pandak

Journal:

Year:

2005

Language:

english

File:

PDF, 905 KB

english, 2005

29

Regulation of Hepatocyte Lipid Metabolism and Inflammatory Response by 25-Hydroxycholesterol and 25-Hydroxycholesterol-3-sulfate

Leyuan Xu, Qianming Bai, Daniel Rodriguez-Agudo, Phillip B. Hylemon, Douglas M. Heuman, William M. Pandak, Shunlin Ren

Journal:

Year:

2010

Language:

english

File:

PDF, 764 KB

english, 2010

30

High-performance liquid chromatography assay for 3β-hydroxy-Δ5-C27-steroid oxidoreductase activity in rat liver microsomes

Phillip B. Hylemon, Leanne Raynor, Patricia M. Bohdan, Z. Reno Vlahcevic

Journal:

Analytical Biochemistry

Year:

1991

Language:

english

File:

PDF, 388 KB

english, 1991

31

Biotransformation of monoterpenes, bile acids, and other isoprenoids in anaerobic ecosystems

P.B. Hylemon, J. Harder

Journal:

FEMS Microbiology Reviews

Year:

1998

Language:

english

File:

PDF, 377 KB

english, 1998

32

Hepatitis B virus X protein increases expression of p21Cip-1/WAF1/MDA6 and p27Kip-1 in primary mouse hepatocytes, leading to reduced cell cycle progression

Liang Qiao, Kevin Leach, Robert McKinstry, Donna Gilfor, Adly Yacoub, Jong Sung Park, Steven Grant, Philip B. Hylemon, Paul B. Fisher, Paul Dent

Journal:

Year:

2001

Language:

english

File:

PDF, 431 KB

english, 2001

33

Activation of the Raf-1/MEK/ERK cascade by bile acids occurs via the epidermal growth factor receptor in primary rat hepatocytes

Yi-Ping Rao, Elaine J. Studer, R.Todd Stravitz, Seema Gupta, Liang Qiao, Paul Dent, Phillip B. Hylemon

Journal:

Year:

2002

Language:

english

File:

PDF, 424 KB

english, 2002

34

Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytes

Liang Qiao, Adly Yacoub, Elaine Studer, Seema Gupta, Xin Yan Pei, Steven Grant, Philip B. Hylemon, Paul Dent

Journal:

Year:

2002

Language:

english

File:

PDF, 331 KB

english, 2002

35

Regulation of oxysterol 7α-hydroxylase (CYP7B1) in primary cultures of rat hepatocytes

William M. Pandak, Phillip B. Hylemon, Shunlin Ren, Dalila Marques, Gregorio Gil, Kaye Redford, Darrell Mallonee, Z.Rano Vlahcevic

Journal:

Year:

2002

Language:

english

File:

PDF, 165 KB

english, 2002

36

Cyclin kinase inhibitor p21 potentiates bile acid–induced apoptosis in hepatocytes that is dependent on p53

Liang Qiao, Robert McKinstry, Seema Gupta, Donna Gilfor, Jolene J. Windle, Philip B. Hylemon, Steven Grant, Paul B. Fisher, Paul Dent

Journal:

Year:

2002

Language:

english

File:

PDF, 299 KB

english, 2002

37

Characterization of a NADH:Flavin oxidoreductase induced by cholic acid in a 7α-dehydroxylating intestinal Eubacterium species

Robert H. Lipsky, Phillip B. Hylemon

Journal:

Biochimica et Biophysica Acta (BBA) - Enzymology

Year:

1980

Language:

english

File:

PDF, 508 KB

english, 1980

38

Expression of the bile acid-inducible NADH:flavin oxidoreductase gene of Eubacterium sp. VPI 12708 in Escherichia coli

Stephen F. Baron, Phillip B. Hylemon

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1995

Language:

english

File:

PDF, 1023 KB

english, 1995

39

Isolation and characterization of a bile acid inducible 7α-dehydroxylating operon in Clostridium hylemonae TN271

Jason M. Ridlon, Dae-Joong Kang, Phillip B. Hylemon

Journal:

Year:

2010

Language:

english

File:

PDF, 788 KB

english, 2010

40

Indinavir alters sterol and fatty acid homeostatic mechanisms in primary rat hepatocytes by increasing levels of activated sterol regulatory element-binding proteins and decreasing cholesterol 7α-hydroxylase mRNA levels

Kris Williams, Yi-Ping Rao, Ramesh Natarajan, W.Michael Pandak, Phillip B. Hylemon

Journal:

Biochemical Pharmacology

Year:

2004

Language:

english

File:

PDF, 679 KB

english, 2004

41

Inhibition of insulin/IGF-1 receptor signaling enhances bile acid toxicity in primary hepatocytes

Paul Dent, Song Iy Han, Clint Mitchell, Elaine Studer, Adly Yacoub, Jennifer Grandis, Steven Grant, Geoffrey W. Krystal, Philip B. Hylemon

Journal:

Biochemical Pharmacology

Year:

2005

Language:

english

File:

PDF, 465 KB

english, 2005

42

HIV protease inhibitor lopinavir-induced TNF-α and IL-6 expression is coupled to the unfolded protein response and ERK signaling pathways in macrophages

Li Chen, Sirikalaya Jarujaron, Xudong Wu, Lixin Sun, Weibin Zha, Guang Liang, Xuan Wang, Emily C. Gurley, Elaine J. Studer, Phillip B. Hylemon, William M. Pandak Jr., Luyong Zhang, Guangji Wang, Xiaok

Journal:

Biochemical Pharmacology

Year:

2009

Language:

english

File:

PDF, 525 KB

english, 2009

43

Biotransformation of monoterpenes, bile acids, and other isoprenoids in anaerobic ecosystems

P.B. Hylemon, J. Harder

Journal:

FEMS Microbiology Reviews

Year:

1998

Language:

english

File:

PDF, 382 KB

english, 1998

44

Bile acids as regulatory molecules

Hylemon, P. B., Zhou, H., Pandak, W. M., Ren, S., Gil, G., Dent, P.

Journal:

The Journal of Lipid Research

Year:

2009

Language:

english

File:

PDF, 1.07 MB

english, 2009

45

Characterization of active and inactive forms of rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase

Terence R. Whitehead, Z.Reno Vlahcevic, Zafarul H. Beg, Phillip B. Hylemon

Journal:

Archives of Biochemistry and Biophysics

Year:

1984

Language:

english

File:

PDF, 3.71 MB

english, 1984

46

Purification and characterization of bile salt hydrolase from Bacteroides fragilis subsp. fragilis

E.J. Stellwag, P.B. Hylemon

Journal:

Biochimica et Biophysica Acta (BBA) - Enzymology

Year:

1976

Language:

english

File:

PDF, 658 KB

english, 1976

47

Partial purification and characterization of NAD-dependent 7α-hydroxysteroid dehydrogenase from Bacteroides thetaiotaomicron

J.A. Sherrod, P.B. Hylemon

Journal:

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

Year:

1977

Language:

english

File:

PDF, 684 KB

english, 1977

48

Partial purification and characterization of NADP-dependent 12α-hydroxysteroid dehydrogenase from clostridium leptum

J.N. Harris, P.B. Hylemon

Journal:

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

Year:

1978

Language:

english

File:

PDF, 677 KB

english, 1978

49

Characterization of a C21 neutral steroid hormone transforming enzyme, 21-dehydroxylase, in crude cell extracts of Eubacterium lentum

S.D. Feighner, V.D. Bokkenheuser, J. Winter, P.B. Hylemon

Journal:

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

Year:

1979

Language:

english

File:

PDF, 705 KB

english, 1979

50

Characterization of 16α-hydroxyprogesterone dehydroxylase in cell extracts of the intestinal anaerobic bacterium, Eubacterium sp. 144

Thomas L. Glass, Robin S. Lamppa, Phillip B. Hylemon

Journal:

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

Year:

1984

Language:

english

File:

PDF, 611 KB

english, 1984